bio/acc manifesto

As computation becomes our substrate for intelligence, biotechnology stands as the foundation for engineering and orchestrating the intelligence inherent in living systems.

By accelerating biotechnology, we are accelerating life and evolution itself. The choice to flourish or perish is ours. We must lead from the heart.

DNA sits at the heart - the ancient, elegant code that orchestrates all living systems. Governed by the algorithm of DNA, biotech delineates the boundary between the animate and the inanimate. Biotech is the embodiment of evolution’s relentless march in time. On the cosmic scale of lightyears, organisms, materials, and objects are merely matter, coalescing into purposeful forms through the crucible of acceleration. This acceleration engenders abundance, flourishing, and the proliferation of life in its myriad expressions.

We stand at the vanguard of a new era, poised to empower the builders, scientists, biohackers, visionaries, and biopunks. Our mission is to accelerate bio-research, democratize bio-data, champion open science, and foster global coordination.

Bio/acc fuels the underground movements, the alchemists of modern elixirs, the neglected patients, the torchbearers of ancient traditions, and the trailblazers of radical progress. Just as cypherpunk rebels liberate software from licenses to generate digital abundance, so biopunk rebels will liberate medicine from the sterile aisles of pharmacies to generate biological abundance. Bio/acc will render the notion of purchasing licensed drugs through pharmacies as optional as purchasing CD keys.

Biotechnologies like CRISPR, mRNA, and bridge recombination have transformed many biological challenges into software problems. This shift to programmable biology aligns with open-source principles that revolutionized the web. Biological intelligence can be freely shared and engineered. The future of biotech innovation lies not in closed labs, but in open networks and distributed experimentation. We must seize this moment to build systems that democratize biological engineering, just as we’ve done with digital technology.

We reject the ten-year, multi-billion-dollar drug development cycles; the precautionary genetic engineering paralysis conservatives; the medical-industrial complex that incentivizes treatments over cures; the establishment peddling addictive substances through the pharmaceutical matrix causing the opioid and amphetamine crisis. We reject the requiem for a dream.

We embrace a revolution in supply chains — direct, efficient, unencumbered. We believe that medicine can be produced at a fraction of current costs through global, open collaboration. Imagine living structures grown organically like trees, integrated with ultra-efficient solar cells that mimic photosynthesis using quantum biology breakthroughs, creating self-sustaining, energy-producing homes. Bio/acc is the clarion call for terrestrial abundance — an unwavering commitment to maximizing the flow of bio-innovation and capital for the greater good of all life.

bio/acc principles

1. DECENTRALIZE biopower

Harness decentralized networks for data storage, transactions and fundraising to build global collectives that fund, coordinate and commercialize scientific research outside the traditional gates and keepers. Build network states with novel regulatory frameworks for safe, open clinical trials.

2. ENGINEER ethical evolution

Biosafety and accountability can be built into the foundations of our technologies through smart contracts. These create immutable records that enable privacy but allow selective disclosure. Communities can define which gene sequences are considered pathogenic and enforce safety parameters. Smart contracts automate fail-safe measures and governance protocols, ensuring rapid response to risks. By leveraging encryption, onchain governance and consensus we create networks where innovation thrives within transparent, community-driven safety standards.

3. ALIGN with ecological blueprints

Integrate biotechnology to be compatible with the natural ecosystems we have neglected,  exploited to the brink of collapse. Embrace the tenets of biomimicry, drawing inspiration from nature’s ingenuity, forms, processes, and systems to propel us forward. Openly design new intelligent life forms that eat plastic, reduce carbon dioxide, and multiply plant life.

4. HACK health, claim mind-body liberty

Assert the inalienable right of all sentient beings to explore and expand their own minds and bodies; to optimize their own neurochemistry and cognition as they see fit. Develop and disseminate new tools for safe and effective self-experimentation of nootropics and psychedelics, from open-source brain-computer interfaces to decentralized patient data-collection. Empower and democratize longevity to prevent declining populations.

5. OPEN-SOURCE the code, spread the wealth

Build a global public commons for research, from genomes to drug designs to experimental protocols, with new decentralized intellectual property frameworks and economic models to ensure the fruits of collective intelligence are shared equitably for the benefit of humanity, not hoarded and monetized by a few, decentralizing IP powered by zero knowledge proofs. Develop instruments that record digital and physical science on distributed file systems. The code of life is a public good, not a trade secret.

6. ACCELERATE supply chains

Develop direct-to-consumer supply chains that radically reduce the cost and time to market. Coordinate global biomanufacturing into open markets and enable access for novel innovation, generics, and existing treatments. 3D print molecules locally.

The bio/acc trinity

Bio/acc is the convergence of biotech, AI and crypto; the onset of a Cambrian explosion in science - one where patients and researchers collaborate across borders, map out entire research fields in hours through knowledge graphs populated by LLMs at breakneck speed, charting the fringes of research and automating outreach to scientists, developing de novo IP onchain through cloud laboratories.

image3

The bio/acc revolution will not be centralized, monetized, or televised. It will be open-sourced, tokenized, and raved.

We need rocket fuel for bio/acc. Not the inflation-financed pools of government grants, regulatory capture capitalism, but a wildfire of scientific and patient communities, open financial protocols, and AI-driven allocation systems. These are the catalysts that will outpace and outperform every traditional model, slashing costs and unleashing scientific abundance and a bio singularity. Macro scale capital formation a la Andrew Lo, at a Manhattan project scale. The Bitcoin of biology.

Crypto allows globally distributed scientific collectives to form and govern capital, build onchain IP and data repositories, test specific therapeutics, circulate breakthroughs and catalyze new ecosystems in service of collective flourishing. As the web evolved from read-write to read-write-own, its symbiosis with biotech will usher in a new paradigm shift: make-evolve-transcend,compressing millions of years of evolution into moments and blocktime.

Bio Singularity

Combined, we are charting a new path to bio singularity, a transformative convergence that redefines life itself. From CRISPR 2.0 and AI-driven protein design in the near term, to whole genome synthesis and bio-digital interfaces in the mid-term, to de-extinction and synthetic ecosystems in the long-term, and ultimately to biological superintelligence and interspecies communication, we will blur the boundaries between natural and artificial, human and machine, Earth and cosmos.

10 year pure exponential Bio/Acceleration Path

The future belongs to the open, the distributed, and the emergent. It belongs to all of us, as co-creators and co-evolvers of the planetary meta-organism.

So, let us go forth and hack the biosphere, not as conquerors but as symbiotic partners. Lest, we fossilize within it.

Let us code new cures and spawn to systems, not in the service of greed but in the pursuit of civilizational flourishing.

Let us make the Anthropocene era not one of human dominance but of human-biosphere collaboration.

The choice is stark: Evolve or expire. Rage against the machine, or replace yourself with one.

For too long, biotechnology has been an extractive industry. It’s time to make it a generative one. It’s time to reanimate the biocene with a spirit of punk audacity. It’s time to upload our evolutionary source code from wetware to software to dreamware.

The future is fermenting; we’re the yeast, beasts, and biohackers. There is no fate but what we make-evolve-transcend.

exponential Bio/Acceleration Path

bioacc.eth

Signed by

Beff Jezos
@BasedBeffJezos
Extropic
John Cumbers
@johncumbers
SynBioBeta
Zen Chu
@accelmed
MIT Hacking Medicine
Ethan Perlstein
@eperlste
Maggie's Pearl
James Brodie
@I_D_Theory
ID Theory
Vincent Weisser
@vincentweisser
Prime Intellect
Paul Kohlhaas
@paulkhls
BIO
Laurence Ion
@longevion
VitaDAO & Vitalia
Amanda Cassatt
@amandacassatt
Serotonin
Stefan George
@StefanDGeorge
Gnosis
Julien Bouteloup
@bneiluj
Stake DAO
Dima Buterin
@dimabuterin
n.a.
Akshay BD
@akshaybd
Solana Labs
Ada Cyborg
@adacyborg11
Alita Transhumanist
Albert Anis
@thealbertanis
ValleyDAO
Kai Micah Mills
@kaimicahmills
CryoDAO
Fisk Antes
@fiskantes
Zee Prime
Christopher Heymann
@HeyoChristopher
1kx
Niklas Anzinger
@NiklasAnzinger
Vitalia City
Alex Miloski
@a_miloski
VitaDAO
Kevin Noessler
@noesslek
Molecule
Stefan Adolf
@stadolf
Molecule
Nicolas Weber
@thenicolasweber
THE DAC
Ed Hesse
@edhesse79
Black Swan
Max Unfried
@maxunfried
National University of Singapore
Leo Nissola
@LeoNissolaMD
Bioenhancement.org
Akasha
@Sky081101
ADVAITA LABS
Tom Howard
@_tomhoward
network0
Manveer
@manveerxyz
Prime Intellect
Vysak Venkateswaran
@vysaksv
University of California Berkeley
Tom Howard
@_tomhoward
network0
Brandon van Houten
@01F1R3
Zelar.City
Brenda
@GordaBitcoin
DeSci LATAM
Shigeru
@0xShigeru
n.a.
Kazuki Tateishi
@No_q64
Gnosis
Art Ramon
@Art_of_Ramon
Arizona Transhumanist Party
Cassian Andor
@mdmalpha1919
AlphaLabs VC
Thomas H. Chapin IV
@tomchapin
Healthspan, Longevity, and AI (community admin)
sirkitree
@sirkitree
ai16z
Rahul Rumalla
@rahulrumalla
Safe
Gabriel Vorbeck
@gabbyvorbeck
The Innovation Game (TIG)
Maryana Kovalchuk
@maryanadcl
Cleveland Clinic
Derya Karli
@DeryaKarl
Sirius Q
mike rice
@agicorp_eth
AGI Corp
Michael Harte
@MichaelLHarte
Molecule/Bio.xyz, Beaker Dao
Mark Melnykowycz
@melnykowycz
Cerebrum DAO
Jack Mgn
@jack_mgn
Vending Machine
webz
@webz2222
Harvard University
Gavin Sathianathan
@gavinho
Research Smart
nahim David
@nahimoxf21
Berachain
Hiro Taiyo Hamada
@hirothamadajp
DeSci Tokyo
Tim Peterson
@timrpeterson
n.a.
Derya Unutmaz, MD
@@DeryaTR_
The Jackson Laboratory
Botao Amber Hu
@bah_eth
Reality Design Lab
Swift Evo
@Swiftevo1
DeSci Asia
Jay Gutierrez
@salvicus2019
NewAtlantis Labs
Sean Brennan
@seanwbren
n.a.
Tyler Quigley
@TyQuig
PsyDAO
Jonas alysas
@Jonas70927106
Vilniaus universitetas
Alex Dobrin
@alxdobrin
VitaDAO
Mgoes
@m_gows_distance
BiohackerDAO
Alyse Sue
@alysesue
Transhuman Coin
Ifeanyi Raymond Uche
@@Ifeanyi22324210
Transhumancoin (THC)
piro osazee
@@mrpirosazee
n.a.
Kazuki Tateishi
@No_q64
Gnosis
Kazuki Tateishi
@No_q64
Gnosis
Art Ramon
@@Art_of_Ramon
Arizona Transhumanist Party
zed
@@0x1908
n.a.
Cassian Andor
@mdmalpha1919
AlphaLabs VC
Alois Hwamiridza
@@ahwamz01
n.a.
CryptoNahue
@crypto_nahue
DeSci LATAM
Electrik Dreams
@electrik_dreams
n.a.
Thomas H. Chapin IV
@tomchapin
Healthspan, Longevity, and AI (community admin)
Alex
@padimaster
n.a.
Mahesh Mannava
@@___Maheshhh
n.a.
sirkitree
@@sirkitree
ai16z
Ehtesham Siddiqui
@ehteshaxm
n.a.
Hemant
@hemantwasthere
MAIT
Snow Ji
@https://x.com/tbeeqgnui?s=21
n.a.
Ginger
@Qsym_99
Three Keys Lab
Sean
@palidor_music
n.a.
Rahul Rumalla
@rahulrumalla
Safe
Anton Lykhoyda
@https://x.com/anton_lykhoyda
n.a.
Karyna Katrich
@karin_katrich
n.a.
Sean Brennan
@seanwbren
n.a.
pipilu
@0x690420
earth
Michael Ferreyros
@KryptoShrimpPhD
University of Colorado - Anschutz
Youssef Gabsi
@gabsiyoussef1
3Sigma
Andy Yee
@ahkyee
ahkyee.com
arthaud mesnard
@arthaud_
stealth
Grant Hummer
@gphummer
n.a.
Steven Zuber
@@stevenxzuber
Bio Protocol
cudo
@rektcudo
n.a.
Precious Alo Zaff
@0xZaff
n.a.
Its Okay To Be Infinite
@oktobeinfinite
n.a.
Gabriel Vorbeck
@gabbyvorbeck
The Innovation Game (TIG)
Keerthiraju Ravichandran
@er_keerthiraju
ICR
ares Wu
@posa88
n.a.
Sebastiano Hakki
@healthsci_ai
HealthSci.AI
Zen Chu
@@accelmed
MIT Hacking Medicine
John Fletcher
@@Dr_JohnFletcher
The Innovation Game
Maryana Kovalchuk
@maryanadcl
Cleveland Clinic
Derya Karli
@@DeryaKarl
Sirius Q
sleeper service
@astrobiopunk
n.a.
James Sinka
@@jamessinka
BIO
mike rice
@@agicorp_eth
AGI Corp
Karl Schmieder
@karlschmieder
Grow Everything
Syed Abdullah
@Syed__abdullah_
n.a.
Jonas Smith
@xx81211360
n.a.
Ares Wu
@posa88
n.a.
cybergang
@@6688bit
n.a.
James Brodie
@I_D_Theory
ID Theory
撸幣.eth
@btc_bafeite
n.a.
Jonas Smith
@xx81211360
n.a.
dalberto Ondricka
@Jonas22255375
n.a.
Romaine Gutmann
@SchneiderT45951
n.a.
Sara Luna
@SaraLun72156504
n.a.
Chris Hernandez
@ChrisHerna88363
n.a.
Patrick Berrington
@PatrickBer83602
n.a.
Michael Harte
@@MichaelLHarte
Molecule/Bio.xyz, Beaker Dao
Axl Anudling
@@Akseeeeeeeeeel
n.a.
Michael Harte
@@MichaelLHarte
Molecule/Bio.xyz, Beaker Dao
Mark Melnykowycz
@melnykowycz
Cerebrum DAO
Jack Mgn
@jack_mgn
Vending Machine
Clemens Ortlepp
@@cl2pp
Bio Protocol
Brian Magierski
@bmagierski
Cerebrum DAO and xponetiq
webz
@@webz2222
Harvard University
Ambrico
@@looknlikelove
n.a.
zhang zane
@ZaneDefi
n.a.
Shigeru
@@0xShigeru
n.a.
Maria Marinova
@m__marinova
n.a.
Gavin Sathianathan
@@gavinho
Research Smart
公喜发财
@@KP3291
n.a.
Ozan Bozkurt
@oznbz
n.a.
nahim David
@@nahimoxf21
Berachain
Hiro Taiyo Hamada
@@hirothamadajp
DeSci Tokyo
Cibus Salvos
@cibussalvos
n.a.
Tim Peterson
@timrpeterson
n.a.
Botao Amber Hu
@bah_eth
Reality Design Lab
CryptoMetal
@cryptometalbr
n.a.
Themis Atsaloglou
@@themisatsal
n.a.
geo
@geovsilalahi
n.a.
Shaman Crowley
@@C9V75
n.a.
Swift Evo
@Swiftevo1
DeSci Asia
bohan sun
@sbh_studio
n.a.
Jay Gutierrez
@@salvicus2019
NewAtlantis Labs
Maria Marinova
@m__marinova
n.a.
Sean Brennan
@@seanwbren
n.a.
Tyler Quigley
@@TyQuig
PsyDAO
Jonas alysas
@Jonas70927106
Vilniaus universitetas
Simon
@@51mson
n.a.
abcovai
@https://x.com/abcovai
n.a.
Ryuuki
@@0xRyUnknown
Tempest Lab
Bagging
@@crypto_bagging
n.a.
Guido Paolo De Felice
@@gippidieffe_
Private DDS, former Fellow Research
Alex Dobrin
@alxd.obrin
VitaDAO
hapip
@@cryptohapip
n.a.
langren
@@langren0325
qinghua
Tsugumi
@@0xTsugumi
n.a.
gary
@@biligo666
n.a.
alfredilo
@@alfredillo_eth
n.a.
Briana
@@BrianaNewbury
n.a.
Godspeed vs Zuckerberg
@Aiadaiyahweh
n.a.
Syambari Herian Atmaja
@syambari247946
Politeknik Negeri Lhokseumawe
mawanshuooo
@@MaWanShuooo
Zhengzhou University of Aeronautics
Dani Aufar
@denaufar
n.a.
Alex Kadet
@@alexey_kadet
Gero.ai
Morgan Rockwell
@@Nodefather
Mycosoft
Dario Russo
@@0xdarior
People DAO
weiqiyou
@@weiqiyou68
University of California Berkeley
Eldar Khamitov
@Eldar_pm
Polymorphic Capital
Young Chae
@@crypto_degen_DA
071 Labs
Francesca Martina
@zk_france
Vitalia
Bahamut
@@TbcBit
Tsinghua University
script (⏱,💰)
@@scriptdotmoney
n.a.
Simon Dedic
@sjdedic
n.a.
OlinPercy
@@HightSkunk42579
Private DDS, former Fellow Research
jorge sanchez
@joxxsc
informatic
Mong Loid
@loidmong
n.a.
Estefano Pinilla Perez
@FanONegative
AthenaDAO and Aarhus University
Dan
@Dan65772536
n.a.

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